Scientific Name: Sus scrofa domestica
Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Laurasiatheria-> Artiodactyla-> Suina-> Suidae-> Sus-> Sus scrofa
Summary: This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] [NCBI] [Proteinatlas]
Data set information
Project | Date | Technology | Tissue | Condition | Cell | PMID/DOI |
---|---|---|---|---|---|---|
Vthunter_0046 | 2021.04 | 10X Genomics | Lung | Normal | 21981 | Link |
Vthunter_0069 | 2021.04 | 10X Genomics | Frontal | Normal | 8812 | Link |
Vthunter_0070 | 2021.04 | 10X Genomics | Occipital | Normal | 6829 | Link |
Vthunter_0071 | 2021.04 | 10X Genomics | Parietal | Normal | 6162 | Link |
Vthunter_0072 | 2021.04 | 10X Genomics | Hypothalamus | Normal | 7302 | Link |
Vthunter_0073 | 2021.04 | 10X Genomics | Temporal | Normal | 3145 | Link |
Vthunter_0074 | 2021.04 | iDrop | Lung | Normal | 13580 | Link |
Vthunter_0074 | 2021.04 | iDrop | Lung | Normal | 13580 | Link |
Vthunter_0074 | 2021.04 | iDrop | Lung | Normal | 13580 | Link |
Vthunter_0074 | 2021.04 | iDrop | Lung | Normal | 13580 | Link |
Vthunter_0074 | 2021.04 | iDrop | Lung | Normal | 13580 | Link |
Vthunter_0074 | 2021.04 | iDrop | Lung | Normal | 13580 | Link |
Vthunter_0074 | 2021.04 | iDrop | Lung | Normal | 13580 | Link |
Vthunter_0074 | 2021.04 | iDrop | Lung | Normal | 13580 | Link |
Vthunter_1013 | 2019.12 | 10X Genomics | Lung | Normal | 7465 | Link |
Vthunter_1014 | 2019.12 | 10X Genomics | Lung | Normal | 3987 | Link |
Featureplot of receptors
Expression: Biased expression in brain (RPKM 11.8) and gall bladder (RPKM 0.8)